This exhibition celebrates the transformative effect of TWO x TWO for AIDS and Art—the annual contemporary art auction held at The Rachofsky House benefiting the Dallas Museum of Art and amfAR, The Foundation for AIDS Research. In the past twenty-five years, the Dallas Museum of Art has acquired over 350 major works of art and organized dozens of shows with the funds raised from this benefit auction. TWO x TWO, with the galvanizing support from the local community, has put Dallas on the map as a global destination for contemporary art. Sections of the exhibition are organized thematically to demonstrate how these funds have allowed the Museum to acquire art that speaks to the most pressing issues in the field. Furthermore, each section highlights the work of an artist who has had a solo exhibition at the DMA, demonstrating the robust, artist-based program TWO x TWO has helped to build at the Museum, allowing it to fulfill its mission to be a force for innovation in contemporary art. We also recognize the immense support TWO x TWO has provided for amfAR, the Foundation for AIDS Research, as the leading annual fundraiser for amfAR in the United States. Over the last twenty-five years, our public understanding and collective memory of AIDS as one of the defining public health crises of this century has continued to evolve. This exhibition serves as a visual testament to those who came before, and whose lives and practices continue to inform and inspire the next generation of artists and makers.